CD28 and neoplasm: In addition, we found that the expression of FCGR3A and HAVCR2 proteins was gradually up-regulated with the increase of Gleason score (GS) grade in tissue samples of different tumor development stages (GS=4+4, high; GS=3+4, medium; GS=2+2, low), among which the expression of FCGR3A was most significantly up-regulated, while the expression of CCR7 and CD28 proteins showed no significant difference (Figure 4C).