MTOR and neoplasm: The abnormal vascularization is the main reason for the restricted diffusion of therapeutic factors inside tumor cells and the hypoxic environment of tumor tissues.47 Intermediate-sized nanoparticles (20–40 nm) were found to help with tumor vasculature normalization.48 Guo et al. used rapamycin as an mTOR inhibitor, which was effective in regularizing the vasculature system of the tumor and enhancing the beneficial impact of cisplatin co-delivery via PLGA with a nanoparticle size of 100 nm.49