Thus, it reverses the hypoxia and consequently may improve the outcomes of traditional cancer treatments.27 There are different types of oxygen-based carriers, including red blood cell (RBC)/hemoglobin (Hb)-based O2 carriers, metal–organic framework (MOF)-based O2 carriers, and perfluorocarbon (PFC)-based O2 carriers, as well as oxygenation by increasing blood flow, as shown in Fig. 3. The gene discussed is GSTM1; the disease is cancer.