have explored the differential expression pattern of circular RNAs (circRNAs) in pulmonary macrophages of sepsis-induced ARDS mice using microarray and found that circN4bp1 affects macrophage differentiation by binding to miR-138-5p, thereby regulating enhancer of zeste homolog 2 (EZH2) expression in vivo and in vitro. This evidence concerns the gene EZH2 and Sepsis.