SMS and cancer: In the TCGA-ccRCC cohort, ARG1, ATP13A2, ATP13A3, AZIN2, OAZ1, OAZ2, OAZ3, PAOX, SMOX, and SRM were highly expressed in cancer tissues, whereas AZIN1, ODC1, SLC18B1, and SMS had low expression levels in cancer tissues, compared with corresponding normal tissues (Figure 1A).