In ICU patients with COVID-19, the quantity of Tregs in PBMCs and their functional molecules (TGF-β and IL-10) were significantly reduced, accompanied by an increased ratio of Th17/Treg cells, RORγt/FoxP3, and IL‐17/IL‐10 in patients compared with the controls (30). The gene discussed is IL17A; the disease is COVID-19.