It is reported that GC cells were heterogeneous, and that PD-L1 in GC cells had different reactivity to GCMSCs and PD-L1 associated with CTCF to contribute to the stemness and self-renewal of GC cells, and GC mesenchymal cells (GCMSCS) enhance the CSC like characteristics of GC cells through PD-L1, resulting in the resistance of GC cells to chemotherapy (62). This evidence concerns the gene CD274 and gastric cancer.