To explore the survival significance of ARGs, we integrated samples from TCGA-COAD and GSE39582 cohort, and investigated the expression levels of ARGs in relation to overall survival (OS) by using Kaplan-Meier analysis, the results showed that 31 ARGs were related with OS and higher expression of most genes (22/31) implied a worse prognosis in COAD patients (Supplementary Figure 1). This evidence concerns the gene SERPINA2 and colon adenocarcinoma.