SPHK1 and neoplasm: In addition, we confirmed the prevalence of CNV alterations in ARGs in COAD patients (Figure 1D), and CNVs seem associated with higher expression of ARGs in tumor tissues, such as NF1, COL4A2, C1GALT1, SPHK1, RUNX1, implying a potential regulatory role of CNVs on the expression of ARGs (Figure 1D).