CD8A and metastatic malignant neoplasm in the lymph nodes: Increased CD8+ TIL levels were closely associated with better survival, lower lymph node metastases, and higher PD-L1 expression levels; the combined evaluation of CD8+ TIL and PD-L1 expression has been used to predict patient responses to PD-1/PD-L1 antibody treatment in a range of malignancies (21).