For example, the ORF73 protein encoded by the murine herpes virus contains a unique SOCS box-like motif that can mediate the assembly of the ElonginC/Cullin5/SOCS-like complex, and the complex mimics the function of the E3 ligase to catalyze the ubiquitination and subsequent proteasome degradation of p65/RelA, ultimately blocking the activation of NF-κB and promoting the continued infection of the virus (180). The gene discussed is RELA; the disease is infection.