MAVS and viral infectious disease: Red-spotted grouper nervous necrosis virus (RGNNV) infection can cause the E3 LjRNF114 of sea perch (Lateolabrax japonicus) to up-regulate, and the up-regulated LjRNF114 boosts the binding of MAVS and TRAF3 to the ubiquitin chains linked to K27 and K48, which leads to MAVS and TRAF3 degrade, RLR signal transduction is destroyed, and ultimately facilitate virus infection (189).