They confirmed synergism of cytokines TNF-α and IFN-γ was capable of inducing PANoptosis of colon cancer cells through activation of GSDMD, GSDME, caspase-8, caspase-3, caspase-7 and MLKL, thereby suppressing tumor growth (110). The gene discussed is GSDMD; the disease is malignant colon neoplasm.