(48) observed that the expression of monocarboxylate transporter 4 (MCT4) was markedly increased in intestinal mucosal tissue of IBD, and overexpression of MCT4 triggered caspase-1/GSDMD-mediated canonical pyroptosis in IECs to aggravate intestinal inflammation through the ERK1/2-NF-kB pathway. Here, NFKB1 is linked to inflammatory bowel disease.