Thioredoxin reductase 3 (Txnrd3) as selenoprotein was recently proved to cause intracellular calcium outflow and increase oxidative stress in colonic epithelial cell line, thereby activating the canonical GSDMD-dependent pyroptosis to inhibit the growth and proliferation of colon cancer cells (82). This evidence concerns the gene GSDMD and malignant colon neoplasm.