A recent study identified that small molecule inhibitors BI 2536 and (S)-(+)-camptothecin via organoid-based drug screen were able to induce GSDME-mediated pyroptosis concurrent with caspase-3-dependent apoptosis, which suppressed CRC tumor growth and enhanced the efficacy of immunotherapy (90). The gene discussed is GSDME; the disease is colorectal carcinoma.