Bromodomain-containing protein 4 (BRD4) was recently found to play a critical role in endotoxemia colon by regulating NLRP3/caspase-1/GSDMD-mediated pyroptosis, and BRD4 inhibition could prevent endotoxemia-induced colon damage through blocking inflammation-related pyroptosis (66). Here, NLRP3 is linked to serum lipopolysaccharide activity.