RIPK1 and Yersinia infectious disease: Moreover, in response to pathogenic Yersinia infection, where the transforming growth factor beta-activated kinase 1 (TAK1) and IκB kinases are blocked by the Yersinia effector protein YopJ, a receptor-interacting protein kinase 1 (RIPK1)-caspase-8 pathway can be activated to cleave GSDMD at this same amino acid site, which provides host defense and maintains homeostasis (36, 37).