GSDMD and colitis: Schisandrin B, a type of natural products, was confirmed to suppress NLRP3/caspase-1/GSDMD-related pyroptosis in IECs of experimental colitis through the activation of AMP-activated protein kinase/Nuclear factor erythroid 2-related factor 2 (AMPK/Nrf2)-dependent reactive oxygen species (ROS)-induced mitochondrial damage (58).