Specifically, SIRT1 suppresses adipogenesis by modifying the activity of PPARγ in preadipocyte and white AT; triggers lipolysis by repressing PPARγ and activating the AMPK pathway; exerts anti-inflammatory effect by repressing NF-κB, NLRP3, and mTOR pathways; and regulates ECM deposition and AT fibrosis. The gene discussed is NLRP3; the disease is ataxia telangiectasia.