Mutant p53 also increases ferroptosis sensitivity of pancreatic cancer cells by downregulating the expression of FTH1 and NCOA4 (145).On the other hand, P53 inhibits ferroptosis by upregulating the expression of cell cycle protein-dependent kinase inhibitor 1A (CDKN1A/p21) (149) and GLS2 (26, 150), which also inhibit the formation of DPP4-NOX1 complex (151) by altering the localization and activity of DPP4 in CRC cells. Here, FTH1 is linked to familial pancreatic carcinoma.