In nucleus, NRF2 forms a heterodimer with sMaf (131) and binds to ARE (132), protecting cancer cells from GPX4 inhibition and promoting the transcription of antioxidant enzymes, such as HMOX1, NOQ1, and GSTS (108, 133–135), reducing ROS levels, forming resistance to ferroptosis (78). The gene discussed is GPX4; the disease is cancer.