Regarding glycemic control, all participants had long standing but well controlled T1D with HbA1c < 8% at start (range 6.4 – 7.6%), which was maintained after tolDC therapy and showed a clear decrease on the long term by an average of 0.34% (range 6.2 – 7.3%, p=0.0029, ANOVA), in spite of constant insulin needs (Figures 3E, F). Here, INS is linked to type 1 diabetes mellitus.