NLRP3 and intervertebral disk degenerative disorder: Surgical induction of LDD and the quantification of disc degeneration were performed, showing significant decreases in disc degeneration from Tmem119p-CreERT2; NLRP3 (fx/fx) mice and significant increases in disc degeneration from Tmem119p-CreERT2; NLRP3mut mice (Figures 5A, B).