Since both exaggerated phagocytosis of microglia and augmentation of pro-inflammatory cytokines may induce severe inflammation and tissue damage (20), it is understandable that attenuation of these effects by NLRP3 KO could improve resolution of the inflammation and prevent LDD, while aggravation of these effects by permanent NLRP3 expression could increase the severity of the inflammation and promote LDD. The gene discussed is NLRP3; the disease is Lhermitte-Duclos disease.