To assess the role of NLRP3 in microglia in LDD, we generated mice with microglia-specific depletion of NLRP3 (Tmem119p-CreERT2; NLRP3 (fx/fx)) and their control NLRP3(fx/fx) mice. The gene discussed is NLRP3; the disease is Lhermitte-Duclos disease.