In the contrast, MM is characterized by malignant plasma cell proliferation that produces M protein (usually >3g/dL) with ≥10% of bone marrow infiltration and is often manifested by end-organ damage commonly known as CRAB criteria (hypercalcemia, renal insufficiency, anemia, bone lytic lesions) (1). This evidence concerns the gene MYOM2 and Miyoshi myopathy.