One of the well-discussed examples is monoclonal gammopathy of renal significance (MGRS), in which kidney damage (e.g., tubulopathy, glomerulopathy, glomerulonephritis) caused by M-protein deposits, involving light chains, heavy chains, or intact immunoglobulins, occurs in the absence of MM or lymphoproliferative disorder. Here, MYOM2 is linked to Miyoshi myopathy.