Then, multivariate Cox regression analysis was performed, and 15 genes were used to construct a Pan-PCD-related prognostic signature in bladder cancer as noted in the following formula: EGR1*0.091+KLF9*(-0.241) + PPP3CB*0.236+FANCD2*(-0.346) +MYC*0.102+ABCB9*0.343+HDAC10*(-0.120) + BECN2*(-0.127) + CHMP4C*(-0.130) + SREBF1*0.169 +TFRC*0.178 + NGF*0.090 + EPDR1*0.115 + CTSE*(-0.045) + FADS2*0.139. The gene discussed is CTSE; the disease is urinary bladder cancer.