We observed similar expression patterns in these datasets, wherein some glycolytic genes showed strong and significant inverse correlations with specific immune genes in specific tumor types (with the strongest negative correlations occurring in ER-negative breast cancer from METABRIC: TPI1 vs. CD3E: r = -0.44, p = 2.39e-22; GSE65904 Melanoma: LDHA vs. CD3E: r = -0.43, p = 6.03e-11; GSE119267 LUAD: ENO1 vs. CD8A: r = -0.43, p = 2.57e-8) (Figure 1B; Supp Figures S1A, B). The gene discussed is ENO1; the disease is melanoma.