Figure 4A shows that pseudotyped lentiviral particles expressing the spike of SARS-CoV-2 and encoding for a fluorescent reporter readily infect 293 cells overexpressing ACE2, and infection is effectively blocked by Imdevimad, as expected (31). The blocking activity percentages obtained in a dose response curve in this cellular assay were comparable to those obtained by the bead-based assay (Figure 4B), showing a strong correlation (Figure 4C). A Brand-Altman analysis demonstrated agreement between both methods (Figure 4D). This evidence concerns the gene ACE2 and infection.