Compared with subjects without gallstone disease, those with gallstone disease were older, more likely to be female, had higher prevalence of hypertension, diabetes, and hyperlipidemia, less likely to smoke tobacco and drink alcohol currently, had higher BMI, more prevalent diagnosis of UAP, less likely to receive PCI, had lower levels of TC, HDL-C, LDL-C, higher levels of HbA1C, lower levels of cTnI and NTproBNP, and less likely to have left ventricular ejection fraction (LVEF) <50%. The gene discussed is NPPB; the disease is hyperlipidemia.