Given the lack of replication studies and the weak significance of the associations in most studies, we investigated the sex-dimorphic effects of the autosomal genes/loci described in the literature with glucose-related traits [e.g., fasting glucose (FG), fasting insulin (FI), T2D], other correlated anthropometric traits including body mass index (BMI), waist to hip ratio (WHR), and GDM, using publicly available data from large genetic consortia, in order to identify the candidate genes with the most robust evidence of sex-dimorphic effect (spanning across multiple phenotypes). This evidence concerns the gene INS and type 2 diabetes mellitus.