Further, maximum run speed corresponding to maximal oxygen uptake and maximum runtime until exhaustion in MetS KKAy+/–ApoE–/– mice were reduced by 24 and 20% respectively, vs non-MetS KKAy–/–ApoE–/– genotypes, and this difference was noted in both sexes (p < 0.005; Figures 2C,D). The gene discussed is APOE; the disease is metabolic syndrome.