In line with earlier findings (34), our data confirm the MetS phenotype of agouti KKAy+/–ApoE–/– mice, characterized by hyperglycemia, obesity, and dyslipidemia, as compared with non-agouti KKAy–/–ApoE–/– littermates. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.