Specifically, while male KKAy+/–ApoE–/– demonstrated 2.5-fold increase in CD45 expression (p < 0.05 vs. male KKAy–/–ApoE–/–), CD45-stained positive area was reduced by 79% in MetS KKAy+/–ApoE–/– vs. non-MetS KKAy–/–ApoE–/– genotypes in female mice (Figure 4B, p < 0.0001). The gene discussed is APOE; the disease is metabolic syndrome.