Pg promotes AAA progression through systemic inflammation using the following mechanism: after entering the blood, Pg binds to the TLR-2 receptor of the abdominal aorta, induces overexpression of MMPs inside the AAA wall or thrombus, and enhances the intraluminal thrombus (ILT) enrichment (55, 57). The gene discussed is JUP; the disease is triple-A syndrome.