The enlarged kidneys were likely a benign response to the high protein content in the 15%Amylose/Soy/FO (14), since a similar increase in kidney weight was observed in earlier studies with different mouse strains fed this same low CHO high protein diet (2, 4) and this was not associated with kidney damage [i.e., albumin secretion (1)]. Here, ALB is linked to Nephropathy.