In our study, B. laterosporus BL1 bacteria intervention remarkably decreased serum IL-1β and TNF-α levels and suppressed hepatic mRNA expression of IL-1β, TNF-α, IL-6, and IFN-γ, indicating that the amelioration of insulin resistance by B. laterosporus BL1 intervention may be attributable to decreases in systemic chronic inflammation. The gene discussed is TNF; the disease is Insulin resistance.