TNF and obesity due to melanocortin 4 receptor deficiency: Given the amelioration of obesity-related complications and intestinal microbiota dysbiosis in HFD-induced obese mice by B. laterosporus BL1, Spearman’s correlation analysis was performed to identify associations between dominant gut bacterial genera and metabolites (SCFAs)/obesity-related parameters (body weight, iWAT weight, eWAT weight, TG, T-CHO, LDL-C, HDL-C, TNF-α, IL-1β, insulin, blood glucose, and HOMA-IR) (Figure 9).