Podoplanin LVD and podoplanin tumoral expression in significant difference with HER2neu agreed with previous studies showing that enhanced intratumoral reactivity of podoplanin was strongly correlated with HER2 overexpression, as measured by immunohistochemistry, and the relationship between increased intratumoral LVD and overexpression of HER2 in gastric cancer patients [41,42]. The gene discussed is ERBB2; the disease is gastric cancer.