Univariate Cox analysis showed that vascular invasion (HR: 3.43, P = 0.012), tumor metastasis (HR: 6.72, P < 0.001), PRETEXT stage (HR: 7.46, P < 0.001), and SERPINE2 (HR: 7.36, P < 0.008) were the prognostic risk factors for hepatoblastoma. Here, SERPINE2 is linked to neoplasm.