Multivariate Cox analysis showed that tumor metastasis (HR: 3.84, P < 0.006), PRETEXT stage (HR: 4.57, P < 0.011), and SERPINE2 (HR: 4.71, P < 0.040) were the independent prognostic risk factors for hepatoblastoma (Table 2). Here, SERPINE2 is linked to neoplasm.