NFE2L2 and hemoglobin measurement: HB is associated with gene mutations such as catenin beta 1 (CTNNB1), NFE2-like BZIP transcription factor 2 (NFE2L2), MYC protooncogene (MYC), and yes-associated transcriptional regulator (YAP), and these gene tests may also be useful indicators for early diagnosis [5].