The APS is a systemic autoimmune illness characterized by venous or arterial thrombosis, obstetric complications, and the presence of antiphospholipid antibodies (aPL) (29), that is, Lupus anticoagulant (LA), anticardiolipin antibody IgM and/or IgG (aCL) and Anti-b2 glycoprotein-I antibody (aB2GP1) IgG and or IgM. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.