pSTAT3 is further related to tumor angiogenesis and metastasis, caused by upregulation of MMP2/9, HGF, bFGF, VEGF, HIP-1α, Twist1, Vimentin, and downregulation of AKT, CXCL10, IL-12, IFN-β/γ, and P53. This evidence concerns the gene AKT1 and neoplasm.