A large body of evidence has shown that the presence of IL-6 may be a marker of persistent inflammation and a direct participant in a comprehensive immune response (Dienz et al., 2012; Spencer et al., 2019; Yousif et al., 2021), IL-6 levels in patients with acute exacerbation were significantly increased compared with those in the stable stage and were positively correlated with viral infection (Hutchinson et al., 2010). Here, IL6 is linked to viral infectious disease.