RPS6KB1 and autosomal dominant polycystic kidney disease: BA also tended to inhibit mTOR and ERK pathway signaling, which are upregulated in ADPKD (Saigusa and Bell, 2015), as evidenced by decreased phosphorylation of P70S6K (Figure 8C) and ERK (Figure 8D), respectively, relative to paired controls in the absence of BA.