IL6 and hereditary elliptocytosis: Although IL-6 is considered anti-inflammatory in the context of acute phase myokines secreted from skeletal muscle, reduced secretion from C2C12 should be considered pro-inflammatory; however since it was triggered by serum from HE athletes under chronic inflammatory status associated with chronic muscle contraction (Sellami et al., 2021b), its reduction was considered anti-inflammatory in this case.