Indeed, the presence of a highly deleterious polymorphic variant in NQO1 is associated with increased cancer risk and affects multiple protein functions through allosteric effects (Lajin and Alachkar, 2013; Pacheco-Garcia et al., 2022b); 3) Over a hundred of missense variants in human NQO1 have been found in human population (i.e. the gnomAD database) or in cancer cell lines as somatic mutations (i.e. the COSMIC database). This evidence concerns the gene NQO1 and cancer.