Furthermore, human SNPs affecting the expression of GSK3B and FXR1 genes in the human prefrontal cortex were shown to interact and affect emotional stability in controls, negative symptoms and antipsychotic drug responsiveness in schizophrenia, as well as symptom severity in bipolar disorder (Del'Guidice et al., 2015; Bureau et al., 2017; Rampino et al., 2021). This evidence concerns the gene FXR1 and bipolar disorder.