SLC6A3 and bipolar disorder: Animal models having elevated dopamine tone resulting from reduced expression of the dopamine transporter (DAT), or administration of pharmacological DAT inhibitors, replicate several motor and cognitive endophenotypes of bipolar disorder, which can be corrected by lithium and other mood stabilizers (Beaulieu et al., 2004; van Enkhuizen et al., 2015; Milienne-Petiot et al., 2017).