Interestingly, St8sia2–/– mice have reduced polysialylation and display schizophrenic-like behaviors including cognitive and behavioral deficits and it was proposed that genetic variation in ST8SIA2 in humans may have the potential to confer a neurodevelopmental predisposition to schizophrenia (Krocher et al., 2015). Here, ST8SIA2 is linked to schizophrenia.