AKT1 and Cognitive impairment: The abnormal composition of these gut microbiota may be a risk factor for common general anesthetics induced neurotoxicity and cognitive impairment in the developing brain, but there are currently few studies on the causal relationship between gut microbiota and general anesthetics induced neurotoxicity and cognitive impairment in the developing brain, and whether it can mediate such neurotoxicity by inhibiting Akt related signaling pathways remains undefined and requires further investigation.