While evaluating brain activity among ε4 carriers with overweight/obesity was interesting and novel, a larger sample would have provided greater statistical power to determine the associations between BMI and working memory related brain activity among ε4 carriers, and we may have been more sufficiently powered to detect APOE genotype × BMI interactions on working memory related brain activity. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.