VASH1 and central nervous system cancer: By constructing the gene and protein PPI map, it was found that VASH1 was mainly associated with microtubule-associated proteins in LGG, which was consistent with the Nieuwenhuis [27] report that VASH1 mutants specifically led to abnormal tyrosineization and de-tyrosylation dynamic circulation of α-tubulin, which was closely related to cell transformation and glioma invasion.