VASH1, on the other hand, acts as an endogenous factor, and its expression feedback line increases during tumor progression, inhibiting tumor growth to some extent, however, because tumor progression is a complex process, its inhibitory effect is limited, resulting in VASH1 only as a biomarker reflecting the role of tumor progression, while its actual inhibitory effect in the microenvironment is limited. Here, VASH1 is linked to neoplasm.