Furthermore, multivariate analysis showed that tumor recurrence (HR = 2.375 and P=0.028), WHO grade (HR = 2.679 and P=0.031), IDH1 wild-type (HR = 6.473 and P < 0.001), and high VASH1 expression (HR = 4.996 and P < 0.002) were independent risk factors for LGG patients (Figure 1(g)) (Table 6). This evidence concerns the gene IDH1 and neoplasm.