Previous studies have indicated that PAK2 dysfunctions are involved in the pathology of autism,[8] 3q29 deletion syndrome,[53, 54] cancer progression,[7] and even flawed blood vessel formation.[10] Consistent with this, blood circulation was among the top enriched function in genes in pseudotime phase 4, underlying the molecule mechanism of hemorrhage in pak2aΔ14 zebrafish embryos.[41] Moreover, heart development, artery development, and heart morphogenesis were also the enriched terms in genes in pseudotime phase 4. This evidence concerns the gene PAK2 and cancer.