Regarding the MR findings of CD33 (SIGLEC‐3) in AD and SIGLEC‐9 in ALS, we note that several members of the SIGLEC protein family have been implicated for roles in neurodegenerative diseases, especially due to neuroinflammatory properties (Siddiqui et al, 2019). This evidence concerns the gene SIGLEC9 and amyotrophic lateral sclerosis.