In PND mouse models, PLX3397 successfully reduced A1-specific astrocytic response and rescued cognitive impairment at early but not late pathological stage [35], whereas PLX5622 remarkably protected mice undergoing tibial fracture from POCD by reducing hippocampal levels of inflammatory cytokines, and abrogating microglial activation and hippocampal recruitment of CCR2 leukocytes [73], which are often accumulated after surgical challenge [37]. The gene discussed is CCR2; the disease is Cognitive impairment.