Since PIK3C2G hypomethylation has been recently found to predict tumor relapse and shorter OS in ovarian cancer [37], the prognostic roles of PIK3C2G CpG in HNSCC were explored through the public database MethSurv (https://biit.cs.ut.ee/methsurv/) [38]. The gene discussed is PIK3C2G; the disease is ovarian carcinoma.