CTLA4 and non-small cell lung carcinoma: Combination immune checkpoint blockade (ICB) immunotherapy with anti-PD-1 & anti-CTLA4 is now in widespread use for unresectable/metastatic melanoma, non-small cell lung cancer (NSCLC) with TPS ≥ 1%, pleural mesothelioma and is currently under intensive evaluation in other oncological indication.