In East Asians, there were two genes with a significant depletion of Neanderthal introgression in liver cancer patients compared to non-affected individuals—NENF (p-value = 3.32 × 10–8, adjusted p-value = 0.0001) and TEDC1 (p-value = 1.11 × 10–5, adjusted p-value = 0.038; Fig. 5B). Here, TEDC1 is linked to liver cancer.