Most of the somatic mutations on the Neanderthal introgressed haplotypes in RARS1 were in noncoding regions (there was one synonymous variant), so likely somatic mutations are not affecting regulation of RARS1. RNH1, ribonuclease/angiogenin inhibitor 1, is important in promoting processing of an miRNA (miR-21) associated with features important in cancer like migration, cell proliferation, invasion, anti-apoptosis, and metastasis [61, 62]. The gene discussed is RNH1; the disease is cancer.