ORL1 is a specific receptor of oxLDL that mediates most functions of oxLDL, such as NF-κB and TNF-α signalling pathway activation, promoting the formation of foam cells in the vasculature and enhancing the proliferation and metastasis of tumour cells (Pirillo et al. 2013; Ma et al. 2019; Poznyak et al. 2020; Feng et al. 2014). Here, TNF is linked to neoplasm.