Our analysis also included the characterization of two tumors with novel BRAF fusion partners, PTPRZ1 and TOP2B. PTPRZ1 is a member of the receptor protein tyrosine phosphatase family that is highly expressed in normal brain tissue and is recurrently fused to MET in adult grade III astrocytomas and secondary glioblastomas [46]. Here, TOP2B is linked to astrocytoma (excluding glioblastoma).