In a PTSD-like rat model, we have recently demonstrated that the FAAH inhibitor URB597 or the direct cannabinoid receptor agonist WIN55,212-2 (Fig. 1) enhanced fear extinction tested 16 days post-trauma, when administered after three spaced extinction sessions, 7, 10 and 13 days after trauma exposure [170]. Here, FAAH is linked to post-traumatic stress disorder.