To strengthen this result we analyzed six cases of GCB and ABC DLBCL subtype, confirming a significantly lower OPN expression in the latter and suggesting that low/absence of OPN may facilitate the occurrence of ABC-DLBCL, in line with the OPN-deficiency described in our spontaneous mouse model (Fig. 7B and Fig.S5). This evidence concerns the gene SPP1 and aneurysmal bone cyst.