SPP1 and diffuse large B-cell lymphoma: Histopathological analysis of OPN-/-Faslpr/lpr spleens showed a subversion of the parenchymal architecture by a monomorphic proliferation of large elements, with abundant cytoplasm and central nuclei, and immunoblastic morphology, suggestive of diffuse large B cell lymphoma with morphology resembling ABC-DLBCL (Fig. 1B).