Also, taking advantage of a publicly available dataset (GSE4475 [38]) comprising 221 DLBCL clinical specimens (58 ABC-, 120 GCB-DLBCL, 43 samples unclassifiable), we observed that SPP1 was downregulated in ABC- versus GCB-DLBCL (FC: 1.75, FDR: 0.0063) (Fig. 7B), confirming the IHC data. The gene discussed is SPP1; the disease is diffuse large B-cell lymphoma.