SPP1 and diffuse large B-cell lymphoma: Among up-regulated genes, we interestingly found Prdm1 [a STAT3-target gene already found enriched in OPN-/-Faslpr/lpr B lymphocytes (Fig. 2D-E)], Prlr and Hsp90b1, all genes that are highly expressed and/or amplified in human ABC-DLBCL samples [31–33].