We found that OPN-/-Faslpr/lpr B cells up-regulated pathways relevant for B cell development and often hyper-activated in several B cell malignancies, including DLBCL, such as NOTCH pathways [34], that, of note, is induced downstream the TLR-mediated activation of STAT3 [35] (Fig. 3B). This evidence concerns the gene SPP1 and diffuse large B-cell lymphoma.