According to mouse findings, we also discovered a highly expressed endosomal OPN in human cell lines of the GC-DLBCL subtype, which, in comparison with the ABC-DLBCL counterpart, is a less aggressive tumor, suggesting that, also in the human setting, the intracellular isoform of OPN may limit the aggressiveness of the disease. The gene discussed is SPP1; the disease is diffuse large B-cell lymphoma.