SPP1 and diffuse large B-cell lymphoma: Although we have clearly demonstrated that the defective expression of intracellular OPN in the lymphoid tissue undergoing remodeling, due to persistent immune stimulation, is a determinant of malignant B cell transformation and acquisition of an ABC-like DLBCL phenotype, our study does not allow envisaging direct or short-term influences on DLBCL diagnosis, prognostication, or treatment.