To assess whether our murine data find correlation with human lymphomas, we performed GSEA applying our list of DEGs between 5-month old OPN-/-Faslpr/lpr and Faslpr/lpr mice to different lymphoma-related signatures and found an enrichment in signatures associated with cell cycle progression and cell proliferation, as well as ABC-DLBCL categorization and IRF4 activation, confirming our results obtained with the spontaneous mouse model (Fig. 3C). Here, SPP1 is linked to aneurysmal bone cyst.