CASP3 and neoplasm: Among them, we highlight protocatechuic acid, which in turn is associated with antitumor activity, due to its chemotherapeutic potential; depending on the concentration used, it can act selectively against human tumor cells, due to the reduction of mitochondrial membrane potential, decreased activity of Na+-K+ ATPase, increase in activated caspases-3 and 8 and DNA fragmentation in lung, liver, cervix, breast and prostate cancer cells, promoting non-cancerous cell survival in lung, breast and prostate without causing membrane damage [25,26].