Similarly, knockout of the Fgf23 of αKlotho genes in mice leads to early lethality caused by unleashed production of 1,25(OH)2D, hypercalcemia, hyperphosphatemia, and ectopic calcifications, a phenotype that can be rescued by concomitant ablation of vitamin D signaling [76,77,78,79,80,81,82,83,84]. This evidence concerns the gene FGF23 and hypercalcemia disease.