Thus, (1) in chronic obstructive pulmonary disease (COPD), GCf1 was strongly associated with the risk of disease [55]; (2) in bronchiectasis, patients carrying the GC1f isoform have a more severe disease and more chronic infections in comparison with those without the GC1f isoform [56]; (3) in inflammatory bowel disease the GC2 isoform was less frequently observed in patients compared with healthy controls, suggesting a protective role [57]. This evidence concerns the gene SLC25A18 and inflammatory bowel disease.